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[Aristolochic acids in herbal medicines].

S Sekita1, H Kamakura, I Yasuda

  • 1sekita@nihs.go.jp

Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo Hokoku = Bulletin of National Institute of Health Sciences
|March 31, 1999
PubMed
Summary

Aristolochic acids, found in Aristolochiaceae plants, have been linked to kidney damage in patients using Chinese herbal medicines. This study quantifies these toxic compounds in related herbs and medicines.

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Area of Science:

  • Toxicology
  • Pharmacology
  • Ethnobotany

Background:

  • Aristolochic acids are naturally occurring nitrophenanthrenes exclusive to the Aristolochiaceae family.
  • Cases of rapidly progressive interstitial renal fibrosis (Chinese herbs nephropathy) have been linked to Chinese herbal medicines containing aristolochic acids.
  • These incidents were reported in Belgium (1993) and Japan (Kansai district).

Purpose of the Study:

  • To quantitatively analyze aristolochic acids in herbal medicines and related plants.
  • To assess the presence of aristolochic acids in Asiasarum Root, a species of Aristolochiaceae listed in the Japanese Pharmacopoeia.

Main Methods:

  • Quantitative analysis of aristolochic acids.
  • Analysis focused on herbal medicines and related plant species from the Aristolochiaceae family.

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Main Results:

  • Aristolochic acids were detected in the Chinese herbal medicines consumed by patients.
  • Quantitative levels of aristolochic acids in specific herbal medicines and related plants were determined.

Conclusions:

  • Confirms the presence of aristolochic acids in implicated herbal medicines.
  • Highlights the potential nephrotoxic risk associated with Aristolochiaceae-containing herbal products.
  • Underscores the importance of quality control and toxicological assessment of traditional medicines.