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[Primary preventive medicine and laboratory medicine]
1Department of Laboratory Medicine, Ohashi Hospital, Toho University School of Medicine, Tokyo.
Rinsho Byori. the Japanese Journal of Clinical Pathology
|March 31, 1999
Summary
This study highlights the importance of nutrition in preventive medicine by establishing dietary reference intakes for the Japanese population. Research on blood nutrient levels aids in setting adequate vitamin intake recommendations and assessing nutritional status.
Area of Science:
- Nutritional Science
- Preventive Medicine
- Clinical Laboratory Science
Context:
- Dietary Reference Intakes (DRI) and Recommended Dietary Allowances (RDAs) are crucial for public health nutrition.
- Establishing reference intervals for nutrient concentrations in blood is essential for setting Adequate Intakes (AI).
- Laboratory assessment of nutritional status is a key component of preventive medicine.
Purpose:
- To adapt U.S. Dietary Reference Intakes (DRI) for the Japanese population.
- To standardize laboratory methods for assessing vitamin levels, exemplified by whole blood vitamin B1 standardization using HPLC.
- To propose the use of national nutrition survey data for setting AI of vitamins.
Summary:
- Introduced U.S. DRI into Japanese RDAs in 1999.
- Standardized whole blood vitamin B1 levels using HPLC in 1997.
- Utilized annual data from 15,000 national nutrition survey participants to inform AI recommendations for vitamins.
- Future reports will include reference intervals for vitamins A, C, and E.
- Advocates for incorporating genetic investigation and stress markers (biopyrrin, uropepsin, urinary 17KS-S) into future preventive medicine.
Impact:
- Provides a foundation for evidence-based nutritional guidelines in Japan.
- Enhances the accuracy of nutritional status assessment through standardized laboratory methods.
- Contributes to the development of effective primary preventive medicine strategies by integrating nutritional and genetic factors.