Experimental models of hypothermic circulatory arrest

This article reviews information obtained from experimental models of hypothermic circulatory arrest, which models have been developed in our and other laboratories over the past several years. The described experiments clearly demonstrate an ability to produce and completely reverse hypothermic circulatory arrest in newborn and developing animals, allowing for a comprehensive evaluation of those physiological variables and therapeutic interventions that would potentially reduce or accentuate ischemic brain damage. Further experiments will allow for a determination of whether or not specific modalities of therapy will reverse secondary systemic complications, thereby allowing for more complete recoverability and ultimately reduced brain damage.