Related Experiment Videos
Multiple gamma c-dependent cytokines regulate T-cell development
T R Malek1, B O Porter, Y W He
1Dept of Microbiology and Immunology, University of Miami School of Medicine, FL 33136, USA. tmalek@mednet.med.miami.edu
Immunology Today
|March 31, 1999
Abstract:
Mutations in the common gamma chain (gamma c) of cytokine receptors account for human X-linked severe combined immunodeficiency disease. gamma c contributes to ligand binding and signaling as a component of five cytokine receptors: interleukin-2-receptor (IL-2R), IL-4R, IL-7R, IL-9R and IL-15R. Here, Thomas Malek and colleagues discuss the contribution of individual gamma c-dependent cytokines in both conventional and intraepithelial T-cell development.