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Liquid phase combinatorial synthesis of benzylpiperazines
1Institute of Chemistry, National Dong Hwa University, Shou-Feng, Hualien, Taiwan.
Bioorganic & Medicinal Chemistry Letters
|March 31, 1999
Abstract:
A novel method for soluble, inexpensive polymer-supported synthesis of piperazine and piperidine libraries on the basis of nucleophilic benzylic substitution and N-acylation is reported. Disubstituted piperazine and piperidine derivatives, that are potential drug candidates, can be isolated in high yields and excellent purity by simple precipitation and washing. This liquid phase method proves to be a useful tool for constructing combinatorial libraries containing diamine moieties.