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Modified PNAs: a simple method for the synthesis of monomeric building blocks
W Maison1, I Schlemminger, O Westerhoff
1Fachbereich Chemie, Universität Oldenburg, Germany.
Bioorganic & Medicinal Chemistry Letters
|March 31, 1999
Abstract:
The synthesis of PNA-monomers with variations in the substitution pattern using the Ugi-Reaction is described. The one-pot procedure leads to new totally protected PNA-monomers which can be selectively cleaved to N-protected monomeric building blocks for PNA synthesis.