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Synthesis and sar of 2- and 3-substituted 7-azaindoles as potential dopamine D4 ligands
N R Curtis1, J J Kulagowski, P D Leeson
1Department of Medicinal Chemistry, Merck Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, UK. Neil_Curtis@Merck.com
Bioorganic & Medicinal Chemistry Letters
|March 31, 1999
Abstract:
7-azaindole compounds bearing a cyclic amine moiety linked by a one or two carbon chain attached at the 2- or 3-position were synthesised and evaluated as potential dopamine D4 ligands. Highest affinity and selectivity for the D4 receptor resided in the 3-aminomethyl-7-azaindole series.