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Nandrolone decanoate for men with osteoporosis
R C Hamdy1, S W Moore, K E Whalen
1James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN USA.
American Journal of Therapeutics
|March 31, 1999
Summary
Nandrolone decanoate combined with calcium carbonate showed transient bone mass increases in men with idiopathic osteoporosis. Further research and careful patient monitoring are recommended due to observed side effects.
Area of Science:
- Endocrinology
- Bone Metabolism
- Pharmacology
Background:
- Idiopathic osteoporosis affects men, leading to reduced bone mineral density.
- Anabolic-androgenic steroids, like nandrolone decanoate, may influence bone metabolism.
- Calcium supplementation is a standard treatment for osteoporosis.
Purpose of the Study:
- To compare the efficacy and safety of nandrolone decanoate plus calcium (NDC) versus calcium alone (CAL) in men with idiopathic osteoporosis.
- To evaluate the impact of NDC on bone mineral density, lean muscle mass, and biochemical parameters.
Main Methods:
- A 12-month randomized, prospective, controlled study in an outpatient setting.
- Twenty-one men with idiopathic osteoporosis were randomized to NDC (50 mg IM weekly + 1000 mg oral calcium daily) or CAL (1000 mg oral calcium daily).
- Bone densitometry and biochemical markers were assessed quarterly.
Main Results:
- The NDC group showed initial bone mineral density increases followed by a decrease to near baseline by 12 months.
- Lean muscle mass changes mirrored bone mineral density fluctuations in the NDC group.
- Significant decreases in free and total testosterone and increases in hemoglobin were observed in the NDC group; no significant changes occurred in the CAL group.
Conclusions:
- Nandrolone decanoate (50 mg IM weekly) transiently increases bone mass in men with idiopathic osteoporosis.
- The anabolic effects on bone appear temporary, necessitating careful monitoring.
- Further investigation into long-term efficacy and safety is warranted.