Related Experiment Video
Updated: Jul 11, 2026

The Dimethylnitrosamine Induced Liver Fibrosis Model in the Rat
Published on: June 17, 2016
Age-dependent changes in rat liver microsomal membrane structure and functions under benzene treatment
1Research Institute of Dermatology and Venerology, Kharkiv, Ukraine. andrey.l.sukhodub@univer.kharkov.ua
Abstract:
The influence of benzene on 3 and 24 months old rat liver microsomes was studied. Some structural and functional changes occur under benzene treatment in the cytochrome P-450 system which are more pronounced in 3 months old rat microsomes than in the 24 months ones. Glucose-6-phosphatase and glucose dehydrogenase activities indicate that 3 months old rat microsomal vesicles are more stable against benzene injury than those, of 24 months old ones. In vitro benzene hydroxylation activation by NADPH addition decreased disruptive xenobiotic's effect on 3 but not on 24 months old rat liver microsomal vesicles. This fact suggests that the rate of benzene hydroxylation is important for its membrane damaging action effect. Thus, age-related differences in xenobiotic action on liver microsomes could be related to the decrease of benzene metabolism rate with senescence.
More Related Videos
05:27Gap Junctional Intercellular Communication: A Functional Biomarker to Assess Adverse Effects of Toxicants and Toxins, and Health Benefits of Natural Products
Published on: December 25, 2016
09:44Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
Published on: November 27, 2019
Related Concept Videos
Reactions at the Benzylic Position: Oxidation and Reduction
Reduction of Benzene to Cyclohexane: Catalytic Hydrogenation
Phase I Reactions: Oxidation of Aliphatic and Aromatic Carbon-Containing Systems
Oxidation reactions are fundamental in aromatic carbon-containing systems. An example is the hydroxylation of phenobarbital, a process that transforms it into...
Pharmacokinetics in Pediatric Patients: Drug Metabolism
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
Bioactivation and Tissue Toxicity