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[Remifentanyl. Indications in anesthesia].

L M Torres1, E Calderón, A Velázquez

  • 1Servicio de Anestesia-Reanimación, Hospital Universitario Puerta del Mar, Cádiz. lmtorres@arrakis.es

Revista Espanola De Anestesiologia Y Reanimacion
|April 1, 1999
PubMed
Summary
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Remifentanil, a potent fentanyl analog, offers rapid anesthesia control but requires careful management due to its quick metabolism. Further studies are needed to evaluate its safety for postoperative analgesia and monitored sedation.

Area of Science:

  • Anesthesiology
  • Pharmacology

Background:

  • Remifentanil is a novel ultra-short-acting opioid analgesic.
  • It is a fentanyl analog developed by Glaxo Wellcome Inc.

Purpose of the Study:

  • To describe the characteristics of remifentanil, a new opioid analgesic.
  • To discuss its implications for anesthesia and postoperative care.

Main Methods:

  • Chemical structure analysis highlighting the methyl-ester group responsible for rapid hydrolysis.
  • Pharmacokinetic properties related to rapid onset and metabolism.

Main Results:

  • Remifentanil's rapid onset and metabolism allow for precise control of anesthetic depth.
  • These properties necessitate proactive planning for postoperative analgesia.

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  • The drug's potency and rapid action require further investigation for safety in awake sedation and postoperative pain management.

    • Conclusions:

    • Remifentanil provides excellent intraoperative anesthetic control due to its unique pharmacokinetic profile.
    • Careful consideration of its rapid metabolism is crucial for effective pain management post-surgery.
    • Additional research is warranted to establish safety protocols for its use in non-anesthetic settings.