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Related Experiment Videos

Does otosclerosis occur only in the temporal bone?

P C Wang1, S N Merchant, M J McKenna

  • 1Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston 02114, USA.

The American Journal of Otology
|April 1, 1999
PubMed
Summary

Otosclerosis, a bone disease, appears confined to the temporal bone. This study found no evidence of otosclerosis in other skeletal sites, suggesting it is not a systemic condition affecting multiple bones.

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Area of Science:

  • Otolaryngology
  • Skeletal Biology
  • Genetics

Background:

  • Otosclerosis is widely assumed to be limited to the temporal bone.
  • This assumption has not been empirically tested.
  • Emerging evidence suggests otosclerosis might be a systemic disease affecting multiple bones.

Observation:

  • Histologic examination of 241 extratemporal bone sections from two patients with clinical otosclerosis was performed.
  • Biopsies were taken from 9 to 11 different skeletal sites per patient.

Findings:

  • No histologic evidence of otosclerosis was found in any nontemporal skeletal bone sections.
  • The study provides 95% confidence that the prevalence of otosclerosis in the extratemporal skeleton of the examined patients is less than 3%.

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Implications:

  • Otosclerosis is unlikely to manifest outside the temporal bone.
  • Unique factors within the otic capsule, such as reduced bone remodeling and the presence of globuli interossei, may predispose it to otosclerosis.