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Related Experiment Videos

Normative melatonin excretion: a multinational study.

L Wetterberg1, J D Bergiannaki, T Paparrigopoulos

  • 1Department of Psychiatry, Karolinska Institute, St. Goran's Hospital, Stockholm, Sweden.

Psychoneuroendocrinology
|April 2, 1999
PubMed
Summary
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This study found that overnight urinary melatonin levels decrease with age and weight in both men and women. Females generally exhibit higher melatonin excretion than males, with two distinct excretion groups identified.

Area of Science:

  • Endocrinology
  • Chronobiology
  • Biochemistry

Background:

  • Melatonin, a hormone regulating sleep-wake cycles, plays roles in various physiological and pathological processes.
  • Understanding melatonin excretion patterns is crucial for interpreting its involvement in health and disease.

Purpose of the Study:

  • To establish a global reference dataset for overnight urinary melatonin levels across diverse demographics.
  • To investigate the relationship between melatonin excretion and factors like age, weight, and gender.

Main Methods:

  • Analysis of overnight urinary melatonin levels in a geographically dispersed population over one year.
  • Inclusion of a broad age range (18-62 years) and both genders.
  • Statistical analysis to identify correlations and distributions.

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Main Results:

  • An inverse correlation was observed between melatonin levels and both age and weight in both genders.
  • Females demonstrated higher mean urinary melatonin levels compared to males.
  • Melatonin excretion showed a bimodal distribution, identifying distinct low and high excretor groups based on age-specific cut-offs.

Conclusions:

  • Overnight urinary melatonin levels are influenced by age, weight, and sex.
  • The identification of low and high melatonin excretor groups suggests distinct physiological profiles.
  • This study provides a valuable reference dataset for non-invasive melatonin assessment in various health conditions.