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Related Experiment Videos

REM sleep behavior disorder and dementia: cognitive differences when compared with AD.

T J Ferman1, B F Boeve, G E Smith

  • 1Department of Psychiatry and Psychology, Mayo Clinic and Foundation, Rochester, MN, USA. ferman.tanis@mayo.edu

Neurology
|April 2, 1999
PubMed
Summary
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Dementia associated with REM sleep behavior disorder (RBD) shows distinct cognitive deficits compared to Alzheimer's disease (AD). This pattern aligns with dementia with Lewy bodies (DLB), suggesting RBD-associated dementia may be DLB.

Area of Science:

  • Neuroscience
  • Neurology
  • Sleep Medicine

Background:

  • Dementia associated with REM sleep behavior disorder (RBD) requires differentiation from Alzheimer's disease (AD).
  • Previous research suggests cognitive differences between dementia with Lewy bodies (DLB) and AD.

Purpose of the Study:

  • To investigate if dementia in RBD patients differs cognitively from AD.
  • To ascertain if these cognitive differences mirror those between DLB and AD.

Main Methods:

  • Retrospective comparison of neurocognitive performance in 31 patients with RBD/dementia versus 31 patients with AD.
  • Groups matched for dementia severity and duration.
  • Diagnosis confirmed by polysomnography and CERAD criteria.

Main Results:

Related Experiment Videos

  • RBD preceded cognitive decline in 94% of patients.
  • RBD/dementia group showed significant deficits in attention, visual memory, and fluency.
  • AD group exhibited significant impairments in naming and verbal memory.
  • Most RBD/dementia patients met criteria for possible/probable DLB.

Conclusions:

  • Dementia in RBD patients exhibits a distinct cognitive profile compared to AD.
  • The observed cognitive differences align with those reported between DLB and AD.
  • Findings suggest dementia associated with RBD may represent a form of DLB.