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Related Experiment Videos

Plasma amino acids during human spaceflight.

T P Stein1, M D Schluter

  • 1Department of Surgery, University of Medicine and Dentistry of New Jersey, School of Osteopathic Medicine, Stratford 08084, USA.

Aviation, Space, and Environmental Medicine
|April 2, 1999
PubMed
Summary
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Spaceflight alters essential amino acid levels, particularly branched-chain amino acids (BCAA). Plasma concentrations of leucine and isoleucine increased during flight, while total essential amino acids decreased upon landing.

Area of Science:

  • Spaceflight physiology
  • Biochemistry
  • Human physiology

Background:

  • Plasma amino acid distribution patterns were analyzed in astronauts before, during, and after space shuttle missions.
  • Samples were collected from crewmembers on the 1993 SLS-2 Columbia Shuttle mission at multiple time points.

Purpose of the Study:

  • To investigate the changes in plasma amino acid profiles during spaceflight.
  • To understand the impact of microgravity on essential amino acid concentrations.

Main Methods:

  • Measurement of plasma amino acid levels using samples collected pre-flight, inflight, and post-flight.
  • Analysis of essential amino acids, with a focus on branched-chain amino acids (BCAA).

Main Results:

Keywords:
NASA Discipline Regulatory PhysiologyNASA Experiment Number 178120 2/2Non-NASA Center

Related Experiment Videos

  • Inflight plasma aminograms on days 8 and 12 were similar but distinct from day 2, which resembled preflight levels.
  • Plasma concentrations of leucine and isoleucine increased significantly with extended time in space.
  • Total essential amino acids and BCAAs decreased upon landing, despite no change in dietary intake.

    • Conclusions:

    • Spaceflight significantly alters plasma amino acid concentrations, particularly essential and branched-chain amino acids.
    • These changes suggest metabolic adaptations to the spaceflight environment.
    • Further research is needed to understand the long-term implications of these metabolic shifts.