[Morphology and pathogenesis of peritonitogenic pancreatitis]

Morphological studies of the pancreas in patients who had died of peritonitis at various periods of its development were carried out. Moreover, an experiment was fulfiled on reproducing peritonitis on 41 dogs. In the pancreas in all sectional observations there was observed a picture of acute inflammatory process of a various degree of intensity (peritonitogenic pancreatitis) depending upon the form of peritonitis. It was established that in pathogenesis of acute peritonitogenic pancreatitis an important role was played by direct transfer of the inflammatory process to the tissue of the gland on the side of the abdominal cavity. At the same time, of great importance were also regurgitation of the intestinal content into the system of the excretory ducts of the gland and hemodynamic disorders. The morphological picture of the reproduced in the experiment on dogs acute peritonitogenic pancreatitis was similar to that in the section observations. Both sectional and experimental data confirm the duct-enzymatic theory, or the theory of "common canal", of the pathogenesis of pancreatitis in general of and peritonitogenic pancreatitis in particular.