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Related Experiment Videos

Experience with osseous implants for bone and biomaterials research.

W C Fox1, T B Aufdemorte

  • 1Department of Otolaryngology--Head and Neck Surgery, The University of Texas Health Science Center at San Antonio.

Journal of Long-Term Effects of Medical Implants
|December 9, 1992
PubMed
Summary

A novel Cancellous Access Port (CAP) implant enables repeated, minimally invasive biopsies of cancellous bone tissue in various animal models. This osseous implant facilitates bone research, drug delivery, and biomaterial assessments with minimal risk.

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Area of Science:

  • Orthopedic research
  • Biomaterials science
  • Animal models in research

Background:

  • Cancellous bone tissue sampling is crucial for understanding bone diseases and evaluating new treatments.
  • Existing methods for cancellous bone biopsy can be invasive and may introduce artifacts.
  • A need exists for a reliable and repeatable method for obtaining unstrained cancellous tissue samples.

Purpose of the Study:

  • To develop and evaluate a novel Cancellous Access Port (CAP) osseous implant.
  • To assess the feasibility of repeated, minimally invasive cancellous tissue sampling in animal models.
  • To explore the utility of the CAP system for pharmaceutical, biologic, and biomaterial studies.

Main Methods:

  • Development of the Cancellous Access Port (CAP) osseous implant.

Related Experiment Videos

  • Testing the CAP system in multiple animal models including baboons, rhesus, sheep, and horses.
  • Utilizing CAP for repeated biopsy of unstrained cancellous tissue.
  • Developing CAP infusion and biopsy core assemblies for specific experimental applications.

    • Main Results:

    • The CAP implant allowed for repeated biopsy of unstrained cancellous bone tissue.
    • The procedure demonstrated minimal morbidity and no mortality across all tested animal species.
    • The CAP system proved effective for administering pharmaceuticals and biologics.
    • CAP facilitated biomaterial implantation/retrieval and studies of bone healing and remodeling.

    Conclusions:

    • The Cancellous Access Port (CAP) is a safe and effective tool for repeated cancellous bone biopsy in experimental settings.
    • The CAP system offers a versatile platform for diverse bone research applications, including drug testing and biomaterial evaluation.
    • This osseous implant significantly advances the ability to study cancellous bone in vivo with minimal invasiveness.