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Related Experiment Videos

Lupus erythematosus and reactive tests for syphilis: update.

R N Shore

    Cutis
    |April 1, 1976
    PubMed
    Summary

    Patients with lupus erythematosus often show false-positive syphilis test results, particularly with the FTA-ABS test. Specific fluorescence patterns may indicate lupus activity, and other tests can help confirm false positives.

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    Area of Science:

    • Immunology
    • Serology
    • Rheumatology

    Background:

    • Lupus erythematosus (LE) patients' sera can interfere with syphilis serologic tests.
    • False-positive results are frequently observed, complicating diagnosis.

    Purpose of the Study:

    • To investigate the occurrence and patterns of false-positive syphilis serologic tests in lupus erythematosus patients.
    • To assess the utility of different syphilis tests in differentiating true from false positives.

    Main Methods:

    • Analysis of serum samples from lupus erythematosus patients.
    • Evaluation of fluorescence patterns in the FTA-ABS test (Fluorescent Treponemal Antibody Absorption test).
    • Comparison with Treponema pallidum Immobilization (TPI) and Microhemagglutination-Treponema pallidum (MHA-TP) tests.

    Main Results:

    • False-positive reactions in FTA-ABS tests were common in LE patients.
    • Beaded fluorescence patterns correlated with anti-DNA antibodies and lupus activity.
    • Borderline and reactive patterns were frequent but not necessarily linked to increased clinical activity.
    • TPI and MHA-TP tests demonstrated utility in identifying false-positive FTA-ABS results.

    Conclusions:

    • Serologic tests for syphilis, including FTA-ABS, can yield false positives in lupus erythematosus.
    • Fluorescence patterns in FTA-ABS tests may offer clues to underlying lupus activity.
    • Confirmatory testing with TPI and MHA-TP is valuable for accurate syphilis diagnosis in LE patients.

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