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Related Experiment Videos

Calciphylaxis: case report and treatment review.

R T Gilson1, E Milum

  • 1Department of Dermatology, Brooke Army Medical Center-Wilford Hall Medical Center, San Antonio, Texas, USA.

Cutis
|April 6, 1999
PubMed
Summary

Calcifying panniculitis, a rare skin condition, caused painful, necrotic lesions in a patient with chronic renal failure and hyperparathyroidism. This case highlights the association between these conditions and the importance of prompt diagnosis.

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Area of Science:

  • Dermatology
  • Nephrology
  • Pathology

Background:

  • Chronic renal failure (CRF) can lead to various systemic complications.
  • Skin manifestations are common in patients with CRF, but calcifying panniculitis is rare.

Observation:

  • A 57-year-old woman with CRF presented with painful, firm, indurated plaques on her lower extremities.
  • The lesions progressed, leading to ulceration and necrosis.
  • Laboratory tests revealed hyperparathyroidism.

Findings:

  • Incisional biopsy confirmed the diagnosis of calcifying panniculitis.
  • This condition involves the deposition of calcium in the subcutaneous fat.
  • The patient's presentation suggests a link between CRF, hyperparathyroidism, and calcifying panniculitis.

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Implications:

  • This case underscores the importance of considering calcifying panniculitis in patients with CRF and hyperparathyroidism presenting with unusual skin lesions.
  • Early diagnosis and management may prevent severe complications like ulceration and necrosis.
  • Further research is needed to elucidate the exact pathophysiological mechanisms linking these conditions.