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[Allergy to hymenoptera venoms in children]
1Service de médecine infantile F (pneumologie, allergologie, mucoviscidose), CHU Purpan, Toulouse, France.
Summary
Hymenoptera venom allergy immunotherapy is effective and well-tolerated in children. This treatment for insect sting allergies shows excellent results, regardless of the protocol used, offering significant benefits for allergic children.
Area of Science:
- Pediatric Allergy and Immunology
- Clinical Toxicology
Background:
- Hymenoptera venom allergy affects 0.4-0.8% of children, with reactions ranging from urticaria to anaphylaxis.
- While fatal reactions are less common than in adults, prompt diagnosis and treatment are crucial.
Purpose of the Study:
- To evaluate the efficacy and tolerability of venom immunotherapy (VIT) in a cohort of pediatric patients.
- To analyze clinical outcomes and immunological changes associated with VIT in children.
Main Methods:
- Retrospective analysis of 91 children undergoing VIT for hymenoptera venom allergy.
- Indications for immunotherapy included clinical history and positive skin tests.
- Various VIT protocols (ultra-rush, accelerated, semi-rush) were utilized.
Main Results:
- Excellent treatment outcomes (90-100%) were observed, consistent with existing literature.
- Clinical presentations included anaphylaxis (15.3%), serious (37.3%), strong (34%), and mild (7.6%) reactions.
- Immunological parameter changes showed individual variations without correlation to treatment outcomes.
Conclusions:
- Venom immunotherapy is a highly effective treatment for hymenoptera venom allergy in children.
- The treatment demonstrates good tolerability across different administration protocols.
- VIT is recommended for children with systemic or generalized reactions to insect stings.