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[Secondary and tertiary prevention of allergic asthma in children]
F Rancé1, A Deschildre, E Bidat
1TSA 70034, Pôle Médicochirurgical de Pédiatrie, Hôpital des Enfants, 330 Avenue de Grande-Bretagne, 31059 Toulouse Cedex, France. rance.f@chu-toulouse.fr
Insights
Defining asthma phenotypes is key for effective prevention and treatment. Specific immunotherapy shows promise in preventing asthma development and new allergies in children.
Area of Science:
- Pulmonology
- Allergology
- Pediatrics
Context:
- Asthma is a lung disease linked to allergy in children, where phenotype expression depends on atopic status.
- Current prevention strategies like allergen avoidance and antihistamines have limited efficacy.
- Better asthma phenotyping is needed for targeted interventions.
Purpose:
- To explore secondary and tertiary prevention strategies for allergic asthma in children.
- To evaluate the effectiveness of allergen avoidance and specific immunotherapy.
- To define the role of immunotherapy in managing allergic asthma.
Summary:
- Secondary prevention focuses on preventing asthma onset and new sensitizations, with immunotherapy showing potential.
- Tertiary prevention aims to reduce symptoms in diagnosed children, requiring environmental management alongside immunotherapy.
- Allergen avoidance alone is insufficient; immunotherapy, combined with background therapy, is recommended per guidelines.
Impact:
- Improved understanding of asthma phenotypes can lead to more precise treatment strategies.
- Specific immunotherapy may prevent asthma progression and new allergic sensitizations.
- Integrated management approaches, including immunotherapy, can enhance outcomes for children with allergic asthma.
Abstract:
Asthma is a disease of the lung epithelial barrier, most often associated with allergy in children. Asthma and allergy are two distinct diseases, but the phenotypic expression of asthma depends on atopic status. A better definition of phenotypes of asthma would result in better targeting of prevention and treatment modalities. Secondary prevention aims to prevent the onset of asthma and the acquisition of new sensitizations in sensitized children. Studies concerning allergen avoidance are insufficient to reach a definitive conclusion and antihistamines have not been shown to be effective. The results for specific immunotherapy suggest a benefit to prevent transition from allergic rhinitis to asthma and the onset of new sensitizations. Tertiary prevention aims to reduce symptoms in children with an existing allergic asthma diagnosis. The avoidance of known respiratory allergens will only be effective in combination with management of the whole environment. Specific immunotherapy has a real place, in combination with background therapy. It should be used according to guidelines in appropriately treated patients.
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