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Who solved the protein folding problem?

¹Center for Applied Molecular Engineering, Institute for Chemistry and Biochemistry, University of Salzburg, Jakob Haringer Strasse 3, A-5020 Salzburg, Austria. sippl@came.sbg.ac.at

Structure (London, England : 1993)

|April 10, 1999

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Protein structure prediction techniques show steady progress, as confirmed by a third worldwide blind test. This assessment reveals advancements and discusses their significant implications for biological sciences.

Area of Science:

Biochemistry and Structural Biology
Computational Biology and Bioinformatics

Background:

Assesses the state-of-the-art in protein structure prediction through a global, blind assessment.
Highlights the critical need for accurate protein structure determination in understanding biological function.

Framework:

Utilizes a rigorous blind testing methodology to evaluate prediction accuracy.
Compares various computational approaches for predicting three-dimensional protein structures.

Implementation:

Analyzes results from the third critical assessment of protein structure prediction methods.
Documents the progress and improvements in prediction accuracy over time.

Implications:

Discusses the impact of improved protein structure prediction on drug discovery and disease research.

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Explores future directions and potential breakthroughs in computational structural biology.