Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Plasticity of temporal information processing in the primary auditory cortex.

M P Kilgard1, M M Merzenich

  • 1Coleman Laboratory, Department of Otolaryngology, University of California at San Francisco 94143-0444, USA. kilgard@phy.ucsf.edu

Nature Neuroscience
|April 10, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cortical map plasticity as a function of vagus nerve stimulation rate.

Brain stimulation·2018
Same author

Effects of vagus nerve stimulation on extinction of conditioned fear and post-traumatic stress disorder symptoms in rats.

Translational psychiatry·2017
Same author

Training sensory signal-to-noise resolution in children with ADHD in a global mental health setting.

Translational psychiatry·2016
Same author

Cortical Map Plasticity as a Function of Vagus Nerve Stimulation Intensity.

Brain stimulation·2015
Same author

Degraded auditory processing in a rat model of autism limits the speech representation in non-primary auditory cortex.

Developmental neurobiology·2014
Same author

Detection and identification of speech sounds using cortical activity patterns.

Neuroscience·2013
Same journal

Glycosylation in Alzheimer's disease.

Nature neuroscience·2026
Same journal

Neuropixels harness the light.

Nature neuroscience·2026
Same journal

Clarity in clearance pathways.

Nature neuroscience·2026
Same journal

Hypothalamic specification in a dish.

Nature neuroscience·2026
Same journal

Author Correction: A route for cerebrospinal fluid flow through leptomeningeal arterial-venous overlaps enables macromolecule and fluid shunting.

Nature neuroscience·2026
Same journal

Author Correction: Prefrontal engrams of long-term fear memory perpetuate pain perception.

Nature neuroscience·2026
See all related articles

Experience can alter auditory cortex neuron response rates. Pairing nucleus basalis stimulation with 15-pps tones increased maximum following rates, while 5-pps tones decreased them, showing experience-driven cortical reorganization.

Area of Science:

  • Neuroscience
  • Auditory Neuroscience
  • Neuroplasticity

Background:

  • Neurons in the rat primary auditory cortex (A1) have a limited maximum following rate for tone sequences, typically around 12 pulses per second (pps).
  • Understanding the capacity for experience-dependent modification of these temporal response properties in adult brains is crucial for neuroscience research.

Purpose of the Study:

  • To investigate whether auditory cortex (A1) neurons in adult rats can modify their maximum following rate through experience.
  • To determine if pairing auditory stimuli with nucleus basalis (NB) stimulation can induce changes in temporal processing capabilities.

Main Methods:

  • Adult rats were subjected to pairing of tone sequences (random carrier frequency, fixed repetition rate) with electrical nucleus basalis (NB) stimulation.

Related Experiment Videos

  • Stimulation occurred 300 to 400 times daily for 20-25 days, using either 5-pps or 15-pps tone trains.
  • Control groups included pairing with fixed carrier frequency 15-pps trains.

    • Main Results:

    • Pairing NB stimulation with 5-pps stimuli significantly decreased the cortical response to rapid stimuli.
    • Pairing NB stimulation with 15-pps stimuli significantly increased the maximum cortical following rate.
    • Pairing with fixed carrier frequency 15-pps trains did not significantly alter the mean maximum following rate.

    Conclusions:

    • This study demonstrates extensive cortical remodeling of temporal response properties in the primary auditory cortex (A1) through experience.
    • Simple differences in spectral and temporal features of sensory input can drive distinct patterns of cortical reorganization, highlighting neuroplasticity.