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[The effect of phenazepam on the pancreatic excretory function in thermal stress]
E U Zakirov1, Kh Ia Karimov, O M Rianskaia
1Department of Pathological Physiology, 2nd Tashkent Medical Institute, Uzbekistan Republic.
Eksperimental'Naia I Klinicheskaia Farmakologiia
|April 13, 1999
Abstract:
The excretory function of the pancreas was studied on albino rats during thermal stress and ACTH (corticotropine) administration. Stress inhibited the enzyme-synthesizing and enzyme-secreting functions of the gland. The tranquilizer phenazepam influencing the GABA-ergic brain systems exerted a protective effect on pancreatic exosecretion in stress and its strength depended on the administration regimen of the drug. Experiments with corticotropine have shown that the antistress effect of phenazepam, to a certain extent is related to its action on the level of ACTH production in the hypophysis.