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Related Concept Videos

Cholinergic Antagonists: Pharmacological Actions01:28

Cholinergic Antagonists: Pharmacological Actions

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Antimuscarinic drugs block muscarinic receptors in multiple systems, including the gut, eye, smooth muscles, respiratory tract, cardiovascular, and central nervous systems. They produce similar effects with varying selectivity depending on the specific agent and tissue. Here are the key pharmacological actions of antimuscarinics:
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Drug Abuse and Addiction: Pharmacological Phenomena01:15

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Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
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Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

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Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Direct-Acting Cholinergic Agonists: Pharmacological Actions00:59

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Direct-acting cholinergic agonists exert their pharmacological actions by mimicking the effects of acetylcholine on postsynaptic muscarinic receptors to generate parasympathetic responses. These agents elicit a range of physiological responses, including cardiovascular effects. For example, activation of muscarinic receptors induces bradycardia, decreased cardiac output, reduced peripheral resistance, and consequent hypotension. In the eye, stimulation of M3 receptors leads to smooth muscle...
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Indirect-Acting Cholinergic Agonists: Pharmacological Actions01:30

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Indirect-acting cholinergic agonists, also known as anticholinesterases, exert their pharmacological effects by enhancing cholinergic transmission in various body parts, including the neuromuscular junction, autonomic cholinergic synapses, and the brain.
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Pharmacological and Functional Genetic Assays to Manipulate Regeneration of the Planarian Dugesia japonica
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PROFESSOR MIKHAIL P. NIKOLAEV AND RUSSIAN PHARMACOLOGY.

V P Fisenko, N G Bondarchuk

    Eksperimental'Naia I Klinicheskaia Farmakologiia
    |August 8, 2018
    PubMed
    Summary
    This summary is machine-generated.

    Professor Mikhail P. Nikolaev significantly advanced drug evaluation and pharmacology through his research and teaching. His contributions span endocrinology, cardiovascular pharmacology, and military pharmacology, shaping the field.

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    Area of Science:

    • Pharmacology
    • Drug Evaluation
    • Medical Education

    Background:

    • This abstract reviews the multifaceted career of Professor Mikhail P. Nikolaev.
    • It highlights his extensive contributions to various pharmacological disciplines.

    Discussion:

    • Professor Nikolaev's research significantly impacted drug evaluation, endocrinological pharmacology, cardiovascular pharmacology, pathological pharmacology, and organotherapy drug discovery.
    • His pedagogical efforts focused on training pharmacology researchers and educators in medical and pharmaceutical universities.

    Key Insights:

    • Analysis of his work in military pharmacology is presented.
    • His instrumental role in establishing the journal "Farmakologiya i Toksikologiya" and the All-Union Scientific Society of Pharmacologists is emphasized.

    Outlook:

    • Professor Nikolaev's legacy continues to influence pharmacological research and education.
    • His foundational work provides a basis for future advancements in drug discovery and development.