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Related Experiment Video

Updated: Oct 7, 2025

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Published on: January 7, 2018

Comparative Informativity of Computing Methods of Insulin Resistance Assessment.

S I Kseneva¹, E V Borodulina², O Yu Trifonova²

¹E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia. viksbest@mail.ru.

Bulletin of Experimental Biology and Medicine

|January 10, 2022

Summary

This summary is machine-generated.

The Quantitative Insulin Sensitivity Check Index (QUICKI) is the most reliable method for assessing insulin resistance in healthy adults. It demonstrates superior reproducibility and minimal variation compared to other indices.

Keywords:

Caro FGIR HOMA-R QUICKI insulin resistance

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Published on: April 23, 2018

Area of Science:

Endocrinology
Metabolic Health
Biostatistics

Background:

Insulin resistance is a key factor in metabolic disorders.
Accurate assessment of insulin sensitivity is crucial for early diagnosis and management.
Several indices exist, but their diagnostic utility varies.

Purpose of the Study:

To comparatively evaluate the reliability of different insulin resistance indices.
To identify the most suitable index for diagnostic criteria in healthy individuals.

Main Methods:

Comparative analysis of insulin resistance indices: HOMA-R, Caro, FGIR, and QUICKI.
Study conducted on 29 healthy volunteers with normal BMI.
Statistical evaluation of variability, reproducibility, and coefficient of variation.

Main Results:

The Quantitative Insulin Sensitivity Check Index (QUICKI) exhibited low variability.
QUICKI demonstrated 100% reproducibility.
QUICKI showed a minimum coefficient of variation among the tested indices.

Conclusions:

QUICKI possesses the essential characteristics for a diagnostic criterion for insulin resistance.
This index offers superior reliability for assessing insulin sensitivity in healthy populations compared to HOMA-R, Caro, and FGIR.