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[The blood-simulating properties of a recombinant colony-stimulating factor and glycyram during cytostatic
A M Dygaĭ1, V V Zhdanov, V I Masycheva
1Institute of Pharmacology, Tomsk Research Center, Russian Academy of Medical Sciences, Russia.
Eksperimental'Naia I Klinicheskaia Farmakologiia
|April 13, 1999
Abstract:
The hemostimulating activity of the drug glycyrram and the recombinant granulocytic-macrophagic colony-stimulating factor (CSF) was compared on models of myelosuppression induced by injection of an alkylating agent cyclophospane (CF) or the antimetabolite 5-fluorouracil (5-FU). It was found that glycerram stimulated hematopoiesis more effectively after 5-FU injection but to a lesser extent (in relation to CSF) in CF injection.