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Updated: Aug 12, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
Published on: November 10, 2013
[The effect of platinum-containing cytostatic preparations on the immune and hematopoietic systems]
1Institute of Pharmacology, Tomsk Research Center, Siberian Branch, Russian Academy of Medical Sciences, Russia.
Abstract:
Experiments on male CBA/CA Lac mice [correction of rats] showed that a maximum tolerance dose of platidiam suppresses the primary humoral immune response stimulated by the thymus-dependent antigen in the late period (30 days), and has practically no immunosuppressive effect at the early stages (4 days) after injection of the cytostatic drug; it raises the phagocytizing activity of the peritoneal macrophages and increases the number of monocytes in the peripheral blood.
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