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Clomipramine-induced urinary retention in a cat
1South Central Veterinary Clinic, Notre-Dame, Manitoba.
Summary
Clomipramine, a medication for psychogenic alopecia in cats, can cause urinary retention due to its anticholinergic effects. This side effect resolved after discontinuing the drug.
Area of Science:
- Veterinary Pharmacology
- Feline Medicine
- Behavioral Pharmacology
Background:
- Psychogenic alopecia is a behavioral issue in cats, often treated with psychotropic medications.
- Clomipramine is a tricyclic antidepressant with known anticholinergic properties.
Observation:
- A 10-year-old spayed female shorthair cat with presumed psychogenic alopecia was administered clomipramine at 1 mg/kg/day.
- Within 48 hours of initiating treatment, the cat exhibited signs of urinary retention.
Findings:
- Discontinuation of clomipramine led to the resolution of urinary retention over a 7-day period.
- The adverse event was directly attributed to the anticholinergic properties of clomipramine.
Implications:
- Clinicians should be aware of the potential anticholinergic side effects of clomipramine in cats, particularly urinary retention.
- Careful monitoring for urinary signs is recommended when prescribing clomipramine for behavioral conditions in felines.
- Alternative treatment strategies or cautious use of clomipramine may be warranted in cats predisposed to urinary issues.