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Neuropeptide Y: a key molecule in anorexia and cachexia in wasting disorders?
1Second Dept of Internal Medicine, Kobe University School of Medicine, Japan. inui@med.kobe-u.ac.jp
Molecular Medicine Today
|April 14, 1999
Abstract:
Anorexia and body weight loss are characteristic of many diseases, including cancer and AIDS. Recent studies indicate that inflammatory cytokines, such as interleukin 1, the interleukin 6 subfamily and tumor necrosis factor, induce anorexia and cachexia by inhibiting the normal adaptive feeding response to energy deficits. Here, I discuss the evidence for and against a central role for neuropeptide Y and leptin in anorexia and cachexia.