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Updated: Aug 4, 2026

Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products
Published on: March 12, 2020
Mining bacterial genomes for antimicrobial targets
1GPC Biotech AG, Fraunhoferstrasse 20, D-82152 Martinsried/Munich, Germany. Hannes.Loferer@gpc-biotech.com
Abstract:
The elucidation of whole-genome sequences is expected to have a revolutionary impact on the discovery of novel medicines. With the availability of complete genome sequences of more than 30 different species, the field of antimicrobial drug discovery has the opportunity to access a remarkable diversity of genomic information. In this review, I summarize how microbial genomics has changed strategies of drug discovery by applying bioinformatics, novel genetic approaches and genomics-based technologies, including analysis of gene expression using DNA microarrays.
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