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Acquired motility disorders in childhood
1Institute of Child Health and Great Ormond Steet Hospital for Children,London, United Kingdom. p.milla@ich.ucl.ac.uk
Summary
Childhood gastrointestinal motility disorders cause symptoms like vomiting and pain due to issues with gut motor control. These conditions stem from nerve, muscle, or central nervous system problems, leading to various syndromes.
Area of Science:
- Pediatric Gastroenterology
- Neurogastroenterology
- Digestive Health
Background:
- Acquired motility disorders in children manifest with significant gastrointestinal (GI) symptoms, including recurrent vomiting, abdominal pain, distension, constipation, and diarrhea.
- These disorders arise from disruptions in the complex control mechanisms governing gut motor activity.
Purpose of the Study:
- To elucidate the pathogenetic mechanisms underlying acquired motility disorders in childhood.
- To describe the spectrum of clinical syndromes resulting from these disorders.
Main Methods:
- Review of underlying pathogenetic mechanisms involving enteric nerves, muscle, humoral factors, and central nervous system input.
- Categorization of resulting clinical syndromes based on severity and presentation.
Main Results:
- Disturbances in gut motor control result from organic disease (enteric nerves/muscle), altered humoral environment, or modified central nervous system input.
- Pathogenetic mechanisms can be congenital or acquired, leading to a range of GI motility syndromes.
Conclusions:
- Acquired motility disorders in children are complex conditions with multifactorial origins affecting gut function.
- Syndromes range from chronic intestinal pseudo-obstruction to irritable bowel syndrome, highlighting a broad clinical spectrum.