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Related Experiment Videos

Central nervous system neuronal migration.

M E Hatten1

  • 1Rockefeller University, New York, New York 10021-6399, USA. hatten@rockvax.rockefeller.edu

Annual Review of Neuroscience
|April 15, 1999
PubMed
Summary
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Cell migrations are crucial for vertebrate brain development, forming structures like the hindbrain and cerebellum. Molecular mechanisms guide these cell movements, offering insights into brain malformations and genetic pathways.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • Cell migration is fundamental to vertebrate brain development, establishing key structures from the early embryo through postnatal stages.
  • Directed cell migration along glial fibers is essential for forming neuronal layers during midgestation.
  • Secondary neurogenesis in postnatal development generates numerous interneurons for specific brain regions.

Purpose of the Study:

  • To summarize the critical roles of cell migration in vertebrate brain development.
  • To highlight molecular factors involved in glial-guided cell migration.
  • To explore common genetic pathways in secondary neurogenesis and insights from neurological mutants.

Main Methods:

  • Review of established knowledge on cell migration during embryonic, midgestation, and postnatal brain development.

Related Experiment Videos

  • Identification of key molecules (astrotactin, glial growth factor, erbB) involved in glial-guided migration.
  • Analysis of gene expression patterns in secondary neurogenesis and studies on neurological mutant mice.

    • Main Results:

    • Widespread cell migrations shape the early embryo, midgestation, and postnatal brain structures.
    • Specific molecules facilitate directed radial migration of postmitotic cells along glial fibers.
    • Common gene expression patterns suggest shared genetic pathways for interneuron development in the cerebellum, hippocampus, and olfactory bulb.

    Conclusions:

    • Cell migration is a conserved and vital process throughout vertebrate brain formation.
    • Understanding molecular guidance mechanisms is key to deciphering neuronal layer formation.
    • Studies on genetic mutations provide crucial insights into brain patterning and malformations.