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Current status of liquid ventilation.

C M Weis¹, W W Fox

¹University of Pennsylvania School of Medicine, Pennsylvania Hospital, Philadelphia 19104, USA.

Current Opinion in Pediatrics

|April 15, 1999

Summary

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Liquid ventilation, using perfluorochemical liquid, has been studied for 30 years. Over 500 patients have received this therapy, but more research is needed to understand its clinical applications.

Area of Science:

Biomedical Engineering
Respiratory Medicine
Critical Care

Background:

Perfluorochemical liquid has been explored for 30 years to improve mechanical ventilation.
Liquid ventilation represents a revolutionary medical therapy with extensive research.
Since 1989, over 500 neonate, pediatric, and adult patients have participated in clinical trials.

Purpose of the Study:

To present current information on liquid ventilation from laboratory and clinical studies.
To provide guidance on patient management for liquid ventilation.
To discuss future research directions for liquid ventilation.

Main Methods:

Review of laboratory-based studies on liquid ventilation.
Analysis of clinical trial data involving liquid ventilation.

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Synthesis of patient management strategies.

Main Results:

Extensive research has been conducted over three decades.
Over 500 human patients have been treated in clinical trials.
Much of the current understanding originates from laboratory findings.

Conclusions:

Liquid ventilation is a well-researched therapeutic concept.
Clinical application relies heavily on ongoing laboratory and clinical data.
Further elucidation of future directions is warranted.