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Updated: Aug 17, 2026
Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
Published on: August 25, 2019
Elevated day 3 serum follicle stimulating hormone and/or estradiol may predict fetal aneuploidy
A Nasseri1, T Mukherjee, J A Grifo
1Department of Obstetrics and Gynecology, Mount Sinai Medical Center, New York, New York 10029, USA.
Objective:
To determine whether baseline serum FSH and/or E2 concentrations can predict the risk for fetal chromosomal abnormalities.
Design:
Case control study.
Setting:
Reproductive technology program at a university hospital.
Patient(S):
Patients who underwent dilation and curettage (D + C), and whose products of conception were karyotyped.
Intervention(S):
Patients underwent natural conception or controlled ovarian hyperstimulation followed by intrauterine insemination, in vitro fertilization and embryo transfer, gamete intrafallopian transfer, or zygote intrafallopian transfer.
Main Outcome Measure(S):
Baseline serum FSH and E2 concentrations and fetal karyotype.
Result(S):
Genetic evaluation of 78 D + C specimens revealed 34 normal and 44 abnormal fetal karyotypes. A significantly greater proportion of women with abnormal fetal karyotype had elevated baseline serum FSH (> or =15 mIU/mL [RIA] or 10 mIU/mL [Immulite]) and/or E2 > or = 50 pg/mL [Immulite]) compared with women of normal fetal karyotype. Among karyotypically abnormal abortuses, autosomal trisomy was the most common abnormality noted (79.5%), followed by mosaicism (6.8%), triploidy (6.8%), monosomy XO (4.5%), and balanced translocation (2.3%).
Conclusion(S):
Baseline serum FSH and/or E2 concentrations may be valuable as predictors of fetal aneuploidy.
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