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Signalling pathways in two-component phosphorelay systems
A L Perraud1, V Weiss, R Gross
1Lehrstuhl für Mikrobiologie, Theodor-Boveri-Institut, Universität Würzburg, Germany.
Trends in Microbiology
|April 21, 1999
Abstract:
Two-component systems are characterized by phosphotransfer reactions involving histidine and aspartate residues in highly conserved signalling domains. Although the basic principles of signal transduction by these systems have been elucidated, several important aspects, such as their integration into more complex cellular regulatory networks and the molecular basis of the specificity of signal transduction, remain unknown.