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Related Experiment Videos

Large degenerated adrenal adenomas: radiologic-pathologic correlation.

J H Newhouse1, C S Heffess, B J Wagner

  • 1Department of Radiology, Armed Forces Institute of Pathology, Washington, DC, USA.

Radiology
|April 20, 1999
PubMed
Summary

Large, degenerated adrenal adenomas often appear heterogeneous and calcified on imaging. Differentiating these from adrenal carcinoma requires surgical resection, as imaging alone is insufficient.

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Area of Science:

  • Radiology
  • Pathology
  • Endocrinology

Background:

  • Large adrenal adenomas can exhibit cystic or heterogeneous features.
  • Degenerative changes within adenomas can mimic other adrenal masses.

Purpose of the Study:

  • To correlate radiologic and pathologic findings of large, degenerated adrenal adenomas.
  • To evaluate the differential diagnosis between adenomas and adrenal carcinomas.

Main Methods:

  • Review of radiologic (CT/MR) and pathologic characteristics of 30 large adrenal adenomas.
  • Comparison with 24 adrenocortical carcinomas to identify differentiating features.

Main Results:

  • Adenomas were often found in asymptomatic women and showed calcification.

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  • Pathology confirmed heterogeneity due to hemorrhage, necrosis, and fibrosis.
  • No definitive imaging features distinguished adenomas from carcinomas.

    • Conclusions:

    • A subset of adrenal adenomas present as larger, heterogeneous, and calcified masses.
    • Central necrosis and hemorrhage contribute to characteristic imaging findings.
    • Distinguishing these adenomas from adrenal carcinoma necessitates surgical resection.