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Fluvoxamine distribution in postmortem cases.

G W Kunsman1, R Rodriguez, P Rodriguez

  • 1Forensic Toxicology Laboratory, Bexar County Medical Examiner's Office, San Antonio, Texas 78229-4565, USA.

The American Journal of Forensic Medicine and Pathology
|April 20, 1999
PubMed
Summary
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This study details the detection and quantification of fluvoxamine in postmortem cases. Fluvoxamine analysis is feasible using standard methods, even with drug tablets for calibration, aiding forensic toxicology.

Area of Science:

  • Forensic Toxicology
  • Analytical Chemistry
  • Pharmacology

Background:

  • Selective serotonin re-uptake inhibitors (SSRIs) like fluvoxamine are commonly prescribed.
  • Accurate postmortem quantification of fluvoxamine is crucial for forensic investigations.
  • Standard analytical methods may require adaptation for postmortem matrices.

Observation:

  • Fluvoxamine was identified in four postmortem cases, two involving intoxication and two incidental findings.
  • The drug was detectable via standard alkaline drug screens and required no derivatization for chromatography.
  • Analysis included central blood, peripheral blood, antemortem blood, bile, vitreous fluid, and urine.

Findings:

  • Postmortem peripheral blood concentrations varied, from 0.5 mg/L (suicide) to 6 mg/L (overdose).

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  • Postmortem redistribution of fluvoxamine was observed in one case comparing central and peripheral blood.
  • Quantification using a fluvoxamine tablet as a calibrator source correlated well with using a pure reference standard.

    • Implications:

    • Standard analytical techniques are effective for detecting and quantifying fluvoxamine in postmortem samples.
    • Fluvoxamine drug tablets can serve as a viable alternative calibrator source when pure reference standards are unavailable.
    • These findings support the reliable use of fluvoxamine analysis in forensic casework and toxicological assessments.