Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Triggering action potentials in an axo-dendritic inhibitory synaptic terminal.

V L Ezrokhi1, L L Voronin

  • 1Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.

Neuroreport
|April 20, 1999
PubMed
Summary

Strychnine application induced seizure-like activity in crayfish neurons. This study reveals antidromic action potentials (APs) near inhibitory terminals, directly impacting neurons and supporting seizure hypotheses.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intracellular tetanization with hyperpolarizing currents potentiates synapses formed by mossy fibers on pyramidal cells in hippocampal field CA3 in rats.

Neuroscience and behavioral physiology·2010
Same author

[Intracellular tetanization by the hyperpolarizing current potentiates synapses formed by mossy fibers on the pyramidal cells of the CA3 hyppocampal area of the rat].

Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova·2009
Same author

Studies of the synaptic plasticity of field CA3 of the hippocampus during tetanization of the perforant path.

Neuroscience and behavioral physiology·2006
Same author

Ephaptic feedback in identified synapses in mollusk neurons.

Neuroscience and behavioral physiology·2005
Same author

Glutamate and GABA are neurotransmitters in the mossy fiber CA3 synapses in the rat neonatal hippocampus.

Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections·2005
Same author

Stimulation of the lateral hypothalamus provokes the initiation of robust long-term potentiation of the thalamo-cortical input to the barrel field of the adult, freely moving rat.

Neuroscience and behavioral physiology·2005

Area of Science:

  • Neuroscience
  • Crustacean neurobiology
  • Synaptic plasticity

Background:

  • The isolated stretch receptor of moulting crayfish is a model for studying neuronal excitability.
  • Strychnine is known to affect neuronal activity by blocking inhibitory neurotransmission.

Purpose of the Study:

  • To investigate the generation and function of antidromic action potentials (APs) in crayfish stretch receptor neurons.
  • To explore the role of increased terminal excitability in seizure-like activity.

Main Methods:

  • Intracellular recording of slow adapting neurone (SAN) activity.
  • Extracellular recording of SAN, fast adapting neurone, and inhibitory fibre action potentials.
  • Application of strychnine to induce changes in neuronal activity.

Related Experiment Videos

Main Results:

  • Strychnine application led to spontaneous APs and seizure-like AP trains.
  • Antidromic APs were observed near inhibitory nerve terminals, preceding postsynaptic potentials.
  • These antidromic APs exerted postsynaptic action via direct and axon reflex mechanisms.

Conclusions:

  • First evidence for antidromic APs generated near inhibitory terminals in this model.
  • Demonstration of direct and axon reflex-mediated actions of antidromic APs on target neurons.
  • Support for the hypothesis that enhanced terminal excitability contributes to seizure activity.