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Related Experiment Videos

Lisinopril improves arterial function in hyperlipidaemia.

A F Lee1, J B Dick, C E Bonnar

  • 1Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, U.K.

Clinical Science (London, England : 1979)
|April 21, 1999
PubMed
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Lisinopril treatment improved arterial function in hypercholesterolaemia patients by enhancing endothelial function. This study suggests angiotensin-converting enzyme inhibitors may benefit cardiovascular health in high cholesterol individuals.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Endothelial dysfunction is a hallmark of hypercholesterolaemia.
  • Animal studies indicate angiotensin-converting enzyme inhibitors (ACEIs) may protect against arterial damage.

Purpose of the Study:

  • To investigate the effect of lisinopril, an ACEI, on endothelial function in patients with hypercholesterolaemia.
  • To assess arterial vasodilatory responses following lisinopril treatment.

Main Methods:

  • A 6-month double-blind, placebo-controlled study involving 40 hypercholesterolaemia patients.
  • Forearm blood flow assessed using venous occlusion plethysmography before and after treatment.
  • Patients received either lisinopril (20 mg/day) or a placebo.

Main Results:

Related Experiment Videos

  • Lisinopril significantly reduced blood pressure in the treatment group.
  • A significant improvement in vasodilatory response to acetylcholine and sodium nitroprusside was observed with lisinopril.
  • No significant changes in vasodilatation were noted in the placebo group.

Conclusions:

  • Six months of lisinopril therapy demonstrates a beneficial effect on arterial function in hyperlipidaemia.
  • Further research is warranted to determine if ACEIs can reduce mortality and morbidity in hypercholesterolaemia.