Effects of fenfluramine and cyproheptadine on growth hormone secretion

The behaviour of GH, its biological behaviour and response to insulin-induced hypoglycemia in obese and underweight patients, of ages varying from 10 to 39 years, was studied before and after treatment wie circadian course of the hormone following adminstration of either drug. Neither did pre-treatment with fenfluramine and cyproheptadine, No modification was noted in the circadian course of the hormaone following administration of either drug. Neither did pre-treatment with cyproheptadine modify the hormonal level in the stimulated test. It was, however, noted that pre-treatment with fenfluramine appears to influence the somatotropinic response to insulin-induced hypoglycemia, yet of different significance in children and adults.