[Morphogenesis of cytoplasmic inclusions in influenza]

Morphogenesis of cytoplasmic inclusions was studied in experimental influenza infection in white mice. It was shown that cytoplasmic inclusions in influenza represented foci of partial degeneration and necrosis of the cytoplasm, the developmental phases of which are similar to phases of formation by means of autolysis. The disintegration of the content of inclusions in the epithelial cells of the bronchi was accompanied by accumulation in their zone of enzyme-containing structures of the type of tegmented vesicles. In low delimitation of inclusions odema of cyto- and karyoplasm was followed by destruction of mitochondria and perish of the cell. Formation of inclusions and signs of reproduction of the virus in alveolar cells proceeded with destruction of osmiophilic bodies. The processes of delimitation of inclusions in cytoplasm was of a reactive character and contributed to preservation of the life activity of cells.