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Plasma protein glycation in Alzheimer's disease
S Riviere1, I Birlouez-Aragon, B Vellas
1Hôpital La Grave-Casselardit, Toulouse, France.
Abstract:
Recent studies have suggested that formation of advanced glycation end-products (AGEs) in some brain proteins could be associated with Alzheimer's disease. These AGEs can be produced by various sugars (hexose, pentose, glyceraldehyde and oxidative products of vitamin C). In this study, we quantified plasma protein glycation specifically derived from glucose in patients with Alzheimer's disease with different grades of cognitive disorders. Two groups of Alzheimer patients were studied: a group with moderate Alzheimer's disease (n = 6, 9
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