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Reversible akinetic mutism possibly induced by baclofen.
1Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
Pharmacotherapy
|April 22, 1999
Summary
A case study reports a 76-year-old man experienced akinetic mutism after low-dose baclofen. Symptoms resolved upon baclofen discontinuation, suggesting a drug-induced neurological effect.
Area of Science:
- Neurology
- Pharmacology
Background:
- Baclofen is a muscle relaxant that acts on GABA-B receptors.
- Akinetic mutism is a rare neurological condition characterized by profound apathy and lack of spontaneous movement or speech.
Observation:
- A 76-year-old male patient developed akinetic mutism after three days of low-dose baclofen administration.
- Electroencephalography revealed diffuse slowing and generalized sharp wave discharges.
Findings:
- This is the first reported instance of baclofen-induced akinetic mutism in an individual with normal renal function.
- The patient's condition fully resolved after discontinuing baclofen treatment.
Implications:
- The findings suggest a potential neurotoxic effect of baclofen, possibly mediated by gamma-aminobutyric acid-B receptor interaction in the frontal lobes or thalamus.
- This case highlights the importance of considering baclofen as a potential cause of akinetic mutism, even in patients with preserved kidney function.