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Related Experiment Videos

Long lasting spasticity in controlled vasospastic angina.

O Ueda1, K Kohchi, Y Kishi

  • 1Department of Cardiology, Chiba Tokushukai Hospital, 1-27-1 Narashinodai, Funabashishi, Chiba 274 8503, Japan.

Heart (British Cardiac Society)
|April 23, 1999
PubMed
Summary

Coronary artery spasm remains inducible in most patients with vasospastic angina even after years of stable remission with antianginal drugs. Continued medication is crucial to prevent high risk of recurrent angina.

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Area of Science:

  • Cardiology
  • Vascular Medicine

Background:

  • Vasospastic angina (VSA) is characterized by reversible coronary artery spasm.
  • Long-term management of VSA typically involves continuous antianginal drug therapy.

Purpose of the Study:

  • To assess the persistence of coronary artery spasticity in patients with VSA who achieved long-term stability with medication.

Main Methods:

  • Follow-up coronary angiography with ergonovine provocation was conducted in 27 well-controlled VSA patients.
  • The interval between initial and follow-up angiography exceeded 24 months.

Main Results:

  • Coronary spasm was inducible in 23 of 27 patients during follow-up.
  • Three patients exhibited 90% narrowing, and one showed diffuse significant narrowing.

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  • No significant difference in spasticity was detected between initial and follow-up tests (p = 0.75).

    • Conclusions:

    • Coronary spasm remains inducible in the majority of VSA patients despite prolonged remission.
    • Discontinuing medication during remission poses a high risk for patients with VSA.