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Related Experiment Videos

The "physiologically effective" correlates: peDk/L and peDk.

R M Hill1

  • 1The Ohio State University, College of Optometry, Columbus 43210-1240, USA.

Optometry and Vision Science : Official Publication of the American Academy of Optometry
|April 23, 1999
PubMed
Summary

New parameters, physiologically effective Dk/L (peDk/L) and peDk, estimate contact lens oxygen performance. This method uses corneal response data to predict lens transmissibility and material permeability for rigid gas permeable lenses.

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Area of Science:

  • Ophthalmic Optics
  • Biomaterials Science
  • Corneal Physiology

Background:

  • Accurate assessment of oxygen transmissibility (Dk/L) and material permeability (Dk) is crucial for contact lens design.
  • Existing models often require known material properties, limiting their application to novel or complex lens designs.

Purpose of the Study:

  • To introduce two novel predictive parameters: physiologically effective Dk/L (peDk/L) and physiologically effective Dk (peDk).
  • To demonstrate a method for estimating Dk/L and Dk values using reverse application of the Residual Hypoxia model.
  • To validate this approach for both simple (single layer) and complex (multi-layer) contact lens oxygen pathways.

Main Methods:

  • Utilized independent databases of physiological corneal responses to hypoxic stress.

Related Experiment Videos

  • Applied a reverse calculation based on Smith's Residual Hypoxia model.
  • Estimated peDk/L and subsequently peDk for single vision rigid gas permeable (RGP) contact lenses with unknown Dk values.
  • Extended the methodology to estimate composite Dk/L and Dk values for multi-layer, multi-material oxygen pathways with unknown parameters.

    • Main Results:

    • Successfully estimated peDk/L and peDk values for RGP contact lenses.
    • Demonstrated the model's capability to predict oxygen pathway properties in complex lens systems.
    • Validated the physiological effectiveness of the derived parameters through independent data.

    Conclusions:

    • The developed parameters (peDk/L, peDk) offer a reliable method for predicting contact lens oxygen performance.
    • This approach enables the estimation of Dk/L and Dk values even when material properties are unknown.
    • The strategy is applicable to a wide range of contact lens designs, from simple to complex, advancing contact lens material assessment.