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Related Experiment Videos

Contact sensitivity to emulsifiers.

M Hannuksela, M Kousa, V Pirilä

    Contact Dermatitis
    |August 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Non-ionic emulsifying agents are safer for eczema patients than triethanolamine stearate. Few patients experienced allergic reactions to common emulsifiers, with glycerol monostearate showing no adverse effects.

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    Area of Science:

    • Dermatology
    • Cosmetic Science
    • Allergology

    Background:

    • Emulsifiers are common ingredients in topical formulations, particularly for dermatological conditions like eczema.
    • Patient sensitivity and potential for irritant or allergic reactions to emulsifiers necessitate careful selection in skincare products.

    Purpose of the Study:

    • To evaluate the safety and potential for irritant and allergic reactions of common emulsifying agents in patients with eczema.
    • To identify specific emulsifiers that may be better tolerated by individuals with compromised skin barriers.

    Main Methods:

    • Patch testing was conducted on over 1,200 patients diagnosed with eczema.
    • Various common emulsifiers, including triethanolamine stearate and non-ionic agents, were applied at specified concentrations (5-20%) in petrolatum.

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  • Irritant and allergic reactions were meticulously recorded and analyzed.

    • Main Results:

    • Triethanolamine stearate (5%) induced irritant reactions in 9.5% of patients.
    • Non-ionic emulsifying agents (10-20%) demonstrated a low incidence of irritation.
    • Overall allergic reactions occurred in 2.1% of patients, with specific agents like Lanette, Spans, and triethanolamine stearate causing reactions in 0.3-0.7%. Glycerol monostearate elicited no reactions. Notably, cross-reactivity was observed between sorbitan sesquioleate and Spans.

    Conclusions:

    • Non-ionic emulsifying agents are generally well-tolerated and preferable to triethanolamine stearate for eczema patients.
    • While most emulsifiers showed low allergic potential, glycerol monostearate appears to be a safe option.
    • Identification of specific sensitivities is crucial for formulating safe and effective topical treatments for eczema.