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Updated: Aug 9, 2026
07:36
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
Infectious disease causes of lymphadenopathy: localized versus diffuse
1Miami Veterans Affairs Medical Center, FL 33125, USA.
Lippincott'S Primary Care Practice
|April 24, 1999
Summary
Lymphadenopathy, or swollen lymph nodes, can indicate various infections. This article reviews how to evaluate lymphadenopathy and discusses common infectious causes of both generalized and regional lymphadenopathy.
Area of Science:
- Infectious Diseases
- Immunology
- Clinical Medicine
Background:
- Lymphadenopathy is a frequent clinical sign associated with a wide spectrum of infectious diseases.
- Evaluating lymphadenopathy involves assessing nodal characteristics, location, associated symptoms, and patient history.
Purpose of the Study:
- To discuss the comprehensive evaluation of lymphadenopathy.
- To identify and describe infectious etiologies of generalized and regional lymphadenopathy.
Main Methods:
- Review of literature on lymphadenopathy evaluation and infectious causes.
- Clinical assessment parameters including node characteristics, location, symptoms, and history.
Main Results:
- Generalized lymphadenopathy can be caused by infections such as human immunodeficiency virus (HIV) disease, toxoplasmosis, secondary syphilis, and tuberculosis.
- Regional lymphadenopathy is also commonly linked to specific infectious processes.
Conclusions:
- A systematic approach to evaluating lymphadenopathy is crucial for identifying underlying infectious causes.
- Recognizing patterns of lymphadenopathy can aid in diagnosing conditions like HIV, toxoplasmosis, syphilis, and tuberculosis.
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