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Related Experiment Videos

The reproducibility of patch tests.

J F Bourke1, K Batta, L Prais

  • 1Birmingham Skin Centre, City Hospital, Dudley Road, Birmingham B18 7QH, U.K. jfbourke@iol.ie

The British Journal of Dermatology
|April 24, 1999
PubMed
Summary
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Duplicate patch testing revealed significant discordance, with 8% of patients showing completely opposite results for allergens. Clinical relevance was low, with only 2% of discordant tests directly linked to patient complaints.

Area of Science:

  • Dermatology
  • Allergology
  • Immunology

Background:

  • Patch testing is crucial for diagnosing allergic contact dermatitis.
  • Reproducibility of patch testing remains a concern, with reported discordant results up to 44%.

Purpose of the Study:

  • To assess the reproducibility of patch testing using simultaneous duplicate tests.
  • To evaluate the clinical relevance of completely discordant patch test results.

Main Methods:

  • 383 patients underwent duplicate patch testing on opposite upper back sides with 10 European standard series allergens.
  • Completely discordant tests (negative on one side, positive on the other) were recorded and analyzed.

Main Results:

  • Completely discordant patch tests occurred in 8% of patients (30/383).

Related Experiment Videos

  • Nickel was the most frequent allergen with discordant results (3%).
  • Only 2% of discordant tests were deemed relevant to the presenting complaint.

    • Conclusions:

    • Significant discordance exists in patch testing, impacting reproducibility.
    • The clinical relevance of completely discordant patch tests is generally low.