Related Experiment Videos
Vitamin E reduces monocyte tissue factor expression in cirrhotic patients
1Department of Internal Medicine, I Clinica Medica, and Department of Therapeutic Medicine, University "La Sapienza," Rome, Italy.
Blood
|April 27, 1999
Summary
In liver cirrhosis, lipid peroxidation contributes to clotting activation. Vitamin E supplementation effectively reduced both lipid peroxidation and clotting markers in cirrhotic patients.
Area of Science:
- Hepatology
- Thrombosis
- Oxidative Stress
Background:
- Clotting activation is observed in liver cirrhosis, but its mechanisms remain unclear.
- Increased lipid peroxidation in cirrhosis suggests a potential link to clotting processes.
Purpose of the Study:
- To investigate the relationship between lipid peroxidation and clotting activation in liver cirrhosis.
- To evaluate the effect of vitamin E on these parameters in cirrhotic patients.
Main Methods:
- Assessed monocyte tissue factor (TF) expression and activity, plasma prothrombin fragment 1+2 (F1+2), and urinary Isoprostane-F2alpha-III in 30 cirrhotic patients and 30 controls.
- Re-evaluated these markers after 30 days of standard therapy with or without vitamin E.
- Performed in vitro analysis of vitamin E's effect on monocyte TF and F1+2 generation.
Main Results:
- Cirrhotic patients exhibited elevated levels of Isoprostane-F2alpha-III, F1+2, and monocyte TF compared to controls.
- Isoprostane-F2alpha-III strongly correlated with F1+2 and TF markers.
- Vitamin E treatment significantly decreased Isoprostane-F2alpha-III, F1+2, and TF, while no changes were observed without vitamin E.
- In vitro, vitamin E reduced monocyte TF expression/activity and F1+2 generation.
Conclusions:
- Lipid peroxidation is closely associated with clotting activation in liver cirrhosis.
- Vitamin E demonstrates a therapeutic potential by reducing both lipid peroxidation and clotting activation in this condition.