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Efficacy of two dose measles vaccination in a community setting

M A Phadke1, I Bhargava, P Dhaigude

  • 1Department of Pediatrics, B.J. Medical College, Pune, India.

Indian Pediatrics
|April 27, 1999
PubMed

Insights

A two-dose measles vaccination schedule, administered six months apart, significantly enhances protection against measles compared to a single dose in community settings. This approach reduces measles incidence effectively.

Area of Science:

  • Public Health
  • Immunization Practices
  • Pediatric Infectious Diseases

Background:

  • Measles remains a significant public health concern globally, necessitating effective vaccination strategies.
  • Single-dose measles vaccination has limitations in achieving long-term immunity in certain populations.
  • Community-based vaccination programs are crucial for disease control.

Purpose of the Study:

  • To evaluate and compare the effectiveness of a two-dose measles vaccination regimen versus a single-dose regimen.
  • To determine the impact of a booster measles dose on disease incidence in a community setting.

Main Methods:

  • Two community blocks with substantial child populations (8990 and 8550, <12 years) were selected for the study.
  • Children aged 9 months to 1 year received the first measles dose; Block A received a second dose (MMR) 6 months later, while Block B received only one dose.
  • A follow-up survey from January 1996 to April 1996 clinically assessed measles cases in both blocks.

Main Results:

  • Block A (two-dose) reported only 3 cases of measles, significantly lower than Block B (single-dose) which had 16 cases (p < 0.01).
  • Key parameters, including cold chain maintenance, were consistent across both study groups, ensuring comparable logistical conditions.

Conclusions:

  • The study demonstrates the superior efficacy of a two-dose measles vaccination schedule over a single dose in a community setting.
  • A six-month interval between measles vaccine doses enhances protective immunity and reduces disease prevalence.
  • Implementing a two-dose strategy is recommended for improved measles control in public health initiatives.
Abstract

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